CICLO DE ESTUDOS PROGRAMA DE PÓS-GRADUAÇÃO EM QUÍMICA 07/122017- 10h
Dia: 07 de dezembro de 2017
Horário: 10 horas
Local: Sala 30 do bloco 09A superior do Departamento de Química da FFCLRP/USP
Why are pharmacy students so afraid of QSAR? Let us break this myth
Dr. Joaquín María Campos Rosa
Granada University, Spain
Resumo: The process of discovering a drug is long, very expensive and full of difficulties. Only one out from 50,000 compounds that are tested will reach the pharmacy shelf. In addition, the entire process can last between 12 and 15 years. Therefore, it is necessary to eliminate or at least reduce this uncertainty.
Quantitative structure-activity relationship (QSAR) is the name applied to methods that correlate molecular structure to some kind of in vitro or in vivo biological properties. QSAR has been invaluable for understanding drug structure-activity relationships for lead discovery and optimization. This technique can allow the design of a drug in a more rational way, shortening the overall process and reducing the enormous economic investment that it entails.
This talk introduces Hansch and Fujita QSAR methods, and I will discuss in a comprehensive way our developments in the field of anticancer drugs by inhibiting an enzyme, which can play a pivotal role in several types of cancer.
OBS: Não será necessária inscrição prévia. Caso seja necessário comprovante de participação, favor solicitar, após o término do evento, ou na secretaria do Departamento de Química, com Lâmia ou através do e-mail dq-pg-quimica@ffclrp.usp.br ou fone (16) 3315-4385.
A PALESTRA SERÁ PROFERIDO EM INGLÊS.